Stacking reference

Supplements for peptide & GLP-1 protocols

The supplements most commonly paired with peptides and GLP-1s — what they're for, typical doses, timing and how they fit alongside your protocol. Educational reference, not medical advice.

Foundation

Creatine monohydrateMuscle and strength preservation — near-default in this crowd.Electrolyte blendSodium/potassium/magnesium to offset reduced intake and hydration loss.MagnesiumConstipation, sleep, and general deficiency — pulls double duty.MultivitaminMicronutrient insurance when food intake drops.Omega-3 (fish oil)Cardiovascular and anti-inflammatory staple (EPA + DHA).Protein powderHitting protein targets — critical on GLP-1s where appetite is suppressed.Vitamin D3Baseline deficiency correction.Vitamin K2Calcium handling; commonly paired with D3.

Muscle & lean mass

BCAAsBranched-chain amino acids.Collagen peptidesSkin, joint, and connective-tissue support.Essential amino acids (EAAs)Muscle protein synthesis support, esp. in a calorie deficit.HMBAnti-catabolic; lean-mass preservation in a deficit.LeucinePrimary trigger of muscle protein synthesis.

GI & digestion

Digestive enzymesBloating and slowed digestion.Fiber (psyllium)Constipation — the top GLP-1 complaint.GingerNausea relief.ProbioticsGut tolerance and regularity.

Micronutrients

B-complexB-vitamin insurance when intake drops.CalciumBone support when dairy/food intake falls.IronOnly where bloodwork shows a gap.Vitamin B12Energy/methylation; liver stores deplete slowly.ZincImmune function and tissue repair.

Metabolic & blood sugar

Alpha-lipoic acid (ALA)Antioxidant and insulin sensitivity.BerberineBlood sugar and lipids — heavily stacked as a 'natural GLP-1' adjacent.ChromiumGlucose metabolism support.Green tea extract (EGCG)Metabolic and antioxidant support.InositolInsulin sensitivity — popular with the PCOS overlap.L-carnitineFatty-acid metabolism.

Joint & tissue repair

BoronBone and hormone support.ChondroitinJoint support, paired with glucosamine.CopperTissue repair — pairs with GHK-Cu and balances zinc.GlucosamineJoint support.Hyaluronic acidJoint and skin hydration.MSMJoint comfort and anti-inflammatory.Vitamin CCollagen-synthesis cofactor and antioxidant — almost always paired with collagen.

Sleep & recovery

ApigeninSleep and recovery.GABARelaxation and sleep.GlycineSleep quality and recovery.L-theanineCalm focus; classic pairing with caffeine.MelatoninSleep onset.ZMAZinc, magnesium, and B6 for recovery.

Skin & anti-aging

AstaxanthinPotent antioxidant; skin and eye support.BiotinHair, skin, and nails.ResveratrolAntioxidant and longevity interest.

Liver & antioxidant

CholineLiver fat handling and methylation.GlutathioneMaster antioxidant.Milk thistleLiver support (silymarin).NACGlutathione precursor; liver and antioxidant support.TUDCALiver/bile support — popular in the AAS- and peptide-stacking community.

Cardiovascular & longevity

CoQ10Mitochondrial and cardiovascular support.L-arginineNitric oxide precursor.L-citrullineNitric oxide and blood flow.NattokinaseFibrinolytic / circulation support.TaurineCardiovascular and longevity interest.

Cognitive & nootropic

Alpha-GPCCholine source for cognition and GH support.CaffeineStimulant — classic pairing with L-theanine.L-tyrosineFocus under stress — pairs with cognitive peptides.Lion's maneNeurotrophic (NGF) interest — chronic effect.

Track supplements alongside your peptides — free

Log supplements and PeptideBuddy charts what's active, builds them into your protocols and reminders.

Create a free account