Leuprolide
Also known as Lupron, Eligard, Leuprorelin
Leuprolide (Lupron) is an approved injection that shuts down sex-hormone production, used for prostate cancer, endometriosis, fibroids, and other hormone-driven conditions.
How one dose clears
modeled over ~6 half-lives- Half-life
- 3.0 h
- Time to peak (Tmax)
- 1.0 h
- Bioavailability
- 94%
- Typical dose
- 1 mg
GnRH receptor agonist used in prostate cancer, endometriosis, central precocious puberty and fertility protocols. Daily SC (immediate-release) or depot.
Mechanism of action
Continuous GnRH-receptor stimulation desensitizes the pituitary, ultimately suppressing LH/FSH and sex-hormone output (after an initial flare).
Approved drug. PK here is immediate-release SC (~3 h); depot formulations release over 1–6 months and are not modeled here. Expect an initial testosterone/estrogen flare.
References
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