Reproductive

Gonadorelin

Also known as GnRH, LHRH, Factrel

Gonadorelin is a lab version of the brain hormone GnRH that tells your pituitary to release LH and FSH — sometimes used alongside testosterone therapy to keep the testes active.

One-dose burn-down
Half-life
18 min
Tmax
12 min
Typical dose
100 mcg

Synthetic gonadotropin-releasing hormone (GnRH) used to stimulate pituitary LH/FSH release. Used off-label on TRT to maintain the HPTA, often as a shorter-acting alternative to HCG.

Mechanism of action

Activates pituitary GnRH receptors to trigger LH and FSH secretion, which in turn stimulate the gonads.

Prescription/research peptide. Plasma half-life is only minutes; the LH/FSH pulse it triggers far outlasts the drug in blood, so the burn-down understates its biological effect.

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Clinical PK context (PMC)

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