NAD+ (Nicotinamide adenine dinucleotide)
Also known as NAD, NAD+, Nicotinamide adenine dinucleotide
NAD+ is a coenzyme every cell uses to make energy, and levels fall with age. It's taken (by injection or IV) hoping to boost energy, recovery, and healthy aging — popular in longevity circles, though human evidence is still thin.
How one dose clears
modeled over ~6 half-lives- Half-life
- 3.0 h
- Time to peak (Tmax)
- 1.0 h
- Typical dose
- 50 mg
A coenzyme central to cellular energy metabolism and DNA repair, used (subcutaneously or by slow IV) in longevity and metabolic-support contexts. Cellular NAD+ levels decline with age.
Mechanism of action
Essential cofactor for redox reactions (NAD+/NADH) and a substrate for sirtuins and PARPs, linking cellular energy status to DNA repair and metabolic regulation. Supplementation aims to raise NAD+ availability (human evidence is preliminary).
References
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