SS-31 (Elamipretide)
Also known as Elamipretide, MTP-131, Bendavia
SS-31 (Elamipretide) is a peptide that targets and protects mitochondria, studied for conditions where the cell's energy machinery is failing.
How one dose clears
modeled over ~6 half-lives- Half-life
- 3.5 h
- Time to peak (Tmax)
- 45 min
- Bioavailability
- 92%
- Typical dose
- 40 mg
Mitochondria-targeting tetrapeptide studied for mitochondrial myopathies and other conditions of mitochondrial dysfunction.
Mechanism of action
Binds cardiolipin on the inner mitochondrial membrane, stabilizing cristae and improving electron transport / ATP production while reducing reactive oxygen species.
Investigational — not FDA approved. Plasma half-life ~3–4 h; mitochondrial retention prolongs effect beyond blood levels.
References
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