Longevity

MOTS-c

Also known as Mitochondrial-derived peptide

MOTS-c is a peptide made by your mitochondria (the cell's power plants), studied for metabolism, insulin sensitivity, and exercise performance.

One-dose burn-down
Half-life
3.0 h
Tmax
30 min
Typical dose
5 mg

A mitochondrial-derived peptide studied for metabolic regulation, insulin sensitivity and exercise capacity.

Mechanism of action

Regulates metabolic homeostasis via AMPK activation; influences glucose metabolism and mitochondrial function (preclinical).

Research peptide — no approved human use. No measured human PK; half-life is a rough estimate from animal data. Often dosed a few times weekly.

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Overview (PDF)

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