Setmelanotide
Also known as Imcivree, RM-493
One-dose burn-down
Half-life
11 h
Tmax
8.0 h
Typical dose
2 mg
Melanocortin-4 receptor agonist for obesity from rare genetic deficiencies (POMC, PCSK1, LEPR) and Bardet–Biedl syndrome. Once-daily SC.
Mechanism of action
Restores hypothalamic melanocortin signaling downstream of leptin, reducing hunger and increasing energy expenditure.
Approved drug (Imcivree). Effective half-life ~11 h. Can cause skin hyperpigmentation and spontaneous erections; monitor.
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