Setmelanotide
Also known as Imcivree, RM-493
Setmelanotide (Imcivree) is an approved daily injection for rare genetic forms of severe obesity, working through the brain's melanocortin appetite pathway to reduce relentless hunger.
Melanocortin-4 receptor agonist for obesity from rare genetic deficiencies (POMC, PCSK1, LEPR) and Bardet–Biedl syndrome. Once-daily SC.
Mechanism of action
Restores hypothalamic melanocortin signaling downstream of leptin, reducing hunger and increasing energy expenditure.
Approved drug (Imcivree). Effective half-life ~11 h. Can cause skin hyperpigmentation and spontaneous erections; monitor.
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