Setmelanotide
Also known as Imcivree, RM-493
Setmelanotide (Imcivree) is an approved daily injection for rare genetic forms of severe obesity, working through the brain's melanocortin appetite pathway to reduce relentless hunger.
How one dose clears
modeled over ~6 half-lives- Half-life
- 11 h
- Time to peak (Tmax)
- 8.0 h
- Typical dose
- 2 mg
Melanocortin-4 receptor agonist for obesity from rare genetic deficiencies (POMC, PCSK1, LEPR) and Bardet–Biedl syndrome. Once-daily SC.
Mechanism of action
Restores hypothalamic melanocortin signaling downstream of leptin, reducing hunger and increasing energy expenditure.
Approved drug (Imcivree). Effective half-life ~11 h. Can cause skin hyperpigmentation and spontaneous erections; monitor.
References
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