Melanotan I (Afamelanotide)
Also known as MT-1, Afamelanotide, Scenesse
Melanotan I (Afamelanotide) makes your skin produce more pigment (a tan). It's approved as a slow-release implant for a rare light-sensitivity condition.
One-dose burn-down
Half-life
1.0 h
Range
30 min–15 h
Tmax
30 min
Bioavailability
100%
Typical dose
500 mcg
Linear α-MSH analog that stimulates melanogenesis (tanning); FDA-approved as a slow-release implant (Scenesse) for erythropoietic protoporphyria.
Mechanism of action
Melanocortin (MC1R) agonist driving eumelanin production.
The approved form is a 16 mg implant with a ~15 h release half-life; the community injectable form clears in ~30–60 min. Injectable use is not approved.
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