Pramlintide (Symlin)
Also known as Symlin
Pramlintide is an approved injectable taken with mealtime insulin that copies the hormone amylin to blunt blood-sugar spikes after eating and help you feel full sooner.
One-dose burn-down
Half-life
48 min
Tmax
20 min
Bioavailability
35%
Steady state
~1d
Typical dose
60 mcg
FDA-approved synthetic amylin analog used with mealtime insulin to improve post-meal glucose and promote satiety. Injected before meals.
Mechanism of action
Amylin receptor agonist that slows gastric emptying, suppresses glucagon, and increases satiety.
Prescription drug. Boxed warning for severe insulin-induced hypoglycemia. Very short half-life (~48 min) — dosed per meal.
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