Cagrilintide
Also known as AM833
Cagrilintide is a once-weekly injectable that mimics amylin, a hormone that signals fullness to your brain — so you eat less. It's being tested for weight loss, often paired with semaglutide (the combo is called CagriSema).
One-dose burn-down
Half-life
7.4 days
Tmax
24 h
Steady state
~35d
Typical dose
0.3 mg
Long-acting amylin analog, often combined with semaglutide (CagriSema). Investigational. Once weekly.
Mechanism of action
Amylin receptor agonist that promotes satiety and slows gastric emptying, complementary to GLP-1 agonism.
Investigational; PK from early trials.
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