Cagrilintide
Also known as AM833
Cagrilintide is a once-weekly injectable that mimics amylin, a hormone that signals fullness to your brain — so you eat less. It's being tested for weight loss, often paired with semaglutide (the combo is called CagriSema).
How one dose clears
modeled over ~6 half-lives- Half-life
- 7.4 days
- Time to peak (Tmax)
- 24 h
- Steady state
- ~35 days
- Typical dose
- 0.3 mg
Long-acting amylin analog, often combined with semaglutide (CagriSema). Investigational. Once weekly.
Mechanism of action
Amylin receptor agonist that promotes satiety and slows gastric emptying, complementary to GLP-1 agonism.
Investigational; PK from early trials.
References
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