Mazdutide
Also known as IBI362, LY3305677
Mazdutide is an experimental weekly injection that activates two hormones (GLP-1 and glucagon) to drive weight loss and improve blood sugar — glucagon adds an extra fat-burning angle.
How one dose clears
modeled over ~6 half-lives- Half-life
- 5.4 days
- Time to peak (Tmax)
- 7.0 h
- Steady state
- ~35 days
- Typical dose
- 1.5 mg
Investigational GLP-1 / glucagon receptor dual agonist (an oxyntomodulin analog) for obesity and diabetes. Once weekly.
Mechanism of action
Oxyntomodulin-based dual agonist pairing GLP-1 incretin effects with glucagon-mediated energy expenditure.
Investigational — not FDA approved. Half-life is poorly constrained in public data (reported ~7–45 days); treat the model as approximate.
References
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