Cotadutide
Also known as MEDI0382
One-dose burn-down
Half-life
13 h
Range
13 h–13 h
Tmax
6.0 h
Typical dose
300 mcg
Investigational dual GLP-1 and glucagon receptor agonist studied for type 2 diabetes, obesity, chronic kidney disease and MASH. Once-daily SC.
Mechanism of action
Balanced GLP-1/glucagon co-agonism pairs appetite suppression and glycemic control with glucagon-driven energy expenditure and hepatic-fat reduction.
Investigational — not approved. Population-PK half-life ~13 h (once-daily dosing).
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