IGF-1 (Mecasermin)
Also known as Mecasermin, Increlex, rhIGF-1
One-dose burn-down
Half-life
5.8 h
Tmax
2.0 h
Bioavailability
100%
Typical dose
40 mcg
Recombinant human insulin-like growth factor 1 for severe primary IGF-1 deficiency. Distinct from the longer-acting analog IGF-1 LR3.
Mechanism of action
Activates the IGF-1 receptor to drive cellular growth and anabolism; circulates largely bound to IGF-binding proteins, extending its half-life.
Approved drug (Increlex). Can cause hypoglycemia — dose with food. Native IGF-1's ~6 h protein-bound half-life differs from IGF-1 LR3.
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