IGF-1 (Mecasermin)
Also known as Mecasermin, Increlex, rhIGF-1
IGF-1 (Mecasermin) is lab-made insulin-like growth factor, approved to treat children who can't grow properly because their bodies don't make enough of it. It drives muscle and tissue growth.
Recombinant human insulin-like growth factor 1 for severe primary IGF-1 deficiency. Distinct from the longer-acting analog IGF-1 LR3.
Mechanism of action
Activates the IGF-1 receptor to drive cellular growth and anabolism; circulates largely bound to IGF-binding proteins, extending its half-life.
Approved drug (Increlex). Can cause hypoglycemia — dose with food. Native IGF-1's ~6 h protein-bound half-life differs from IGF-1 LR3.
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