IGF-1 (Mecasermin)
Also known as Mecasermin, Increlex, rhIGF-1
IGF-1 (Mecasermin) is lab-made insulin-like growth factor, approved to treat children who can't grow properly because their bodies don't make enough of it. It drives muscle and tissue growth.
How one dose clears
modeled over ~6 half-lives- Half-life
- 5.8 h
- Time to peak (Tmax)
- 2.0 h
- Bioavailability
- 100%
- Typical dose
- 40 mcg
Recombinant human insulin-like growth factor 1 for severe primary IGF-1 deficiency. Distinct from the longer-acting analog IGF-1 LR3.
Mechanism of action
Activates the IGF-1 receptor to drive cellular growth and anabolism; circulates largely bound to IGF-binding proteins, extending its half-life.
Approved drug (Increlex). Can cause hypoglycemia — dose with food. Native IGF-1's ~6 h protein-bound half-life differs from IGF-1 LR3.
References
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