Vasoactive Intestinal Peptide (VIP)
Also known as VIP, Aviptadil
One-dose burn-down
Half-life
2 min
Tmax
3 min
Typical dose
50 mcg
A 28-amino-acid vasoactive peptide; the synthetic form aviptadil has been studied in ARDS and pulmonary conditions.
Mechanism of action
Agonizes VPAC1/VPAC2 receptors, causing vasodilation, bronchodilation and immunomodulation.
Research/early-clinical — not broadly approved. Extremely short plasma half-life (~1–2 min); inhaled or infused formulations behave very differently from this estimate.
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