Vasoactive Intestinal Peptide (VIP)
Also known as VIP, Aviptadil
VIP (Vasoactive Intestinal Peptide) is a natural signaling molecule that relaxes blood vessels and calms inflammation — used (unapproved, often as a nasal spray) for chronic inflammatory and immune issues.
How one dose clears
modeled over ~6 half-lives- Half-life
- 2 min
- Time to peak (Tmax)
- 3 min
- Typical dose
- 50 mcg
A 28-amino-acid vasoactive peptide; the synthetic form aviptadil has been studied in ARDS and pulmonary conditions.
Mechanism of action
Agonizes VPAC1/VPAC2 receptors, causing vasodilation, bronchodilation and immunomodulation.
Research/early-clinical — not broadly approved. Extremely short plasma half-life (~1–2 min); inhaled or infused formulations behave very differently from this estimate.
References
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