PACAP-38
Also known as Pituitary adenylate cyclase-activating polypeptide
One-dose burn-down
Half-life
7 min
Tmax
6 min
Typical dose
100 mcg
A 38-amino-acid neuropeptide studied in migraine, neuroprotection and metabolism research.
Mechanism of action
Activates PAC1/VPAC receptors and raises cAMP; a potent vasodilator and neuromodulator implicated in migraine.
Research peptide — not approved. Cleared from plasma within minutes (half-life ~5–10 min); can trigger flushing and headache.
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