PACAP-38
Also known as Pituitary adenylate cyclase-activating polypeptide
PACAP-38 is a signaling peptide involved in stress, metabolism, and nerve protection — studied in research for brain and metabolic conditions (and, at high levels, migraine). Experimental.
How one dose clears
modeled over ~6 half-lives- Half-life
- 7 min
- Time to peak (Tmax)
- 6 min
- Typical dose
- 100 mcg
A 38-amino-acid neuropeptide studied in migraine, neuroprotection and metabolism research.
Mechanism of action
Activates PAC1/VPAC receptors and raises cAMP; a potent vasodilator and neuromodulator implicated in migraine.
Research peptide — not approved. Cleared from plasma within minutes (half-life ~5–10 min); can trigger flushing and headache.
References
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