Teriparatide
Also known as Forteo, PTH(1-34), PTH 1-34, Bonsity
Teriparatide (Forteo) is an approved daily injection — a piece of parathyroid hormone — that stimulates new bone growth to treat severe osteoporosis.
How one dose clears
modeled over ~6 half-lives- Half-life
- 1.0 h
- Time to peak (Tmax)
- 30 min
- Bioavailability
- 95%
- Typical dose
- 20 mcg
Recombinant N-terminal fragment of parathyroid hormone (PTH 1-34) used to build bone in severe osteoporosis. Dosed once daily subcutaneously.
Mechanism of action
Intermittent PTH-receptor activation favors osteoblastic bone formation over resorption, raising bone mineral density.
Approved drug (Forteo). Serum half-life is ~1 h after SC dosing even though the biologic effect lasts longer. The former osteosarcoma boxed warning (rodent data) was removed in 2020.
References
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