Dulaglutide
Also known as Trulicity
Dulaglutide (Trulicity) is a once-weekly diabetes injection in the GLP-1 family that lowers blood sugar and reduces appetite.
How one dose clears
modeled over ~6 half-lives- Half-life
- 4.7 days
- Time to peak (Tmax)
- 36 h
- Bioavailability
- 65%
- Steady state
- ~14 days
- Typical dose
- 0.75 mg
Once-weekly GLP-1 receptor agonist for type 2 diabetes.
Mechanism of action
GLP-1 analog fused to an IgG4 Fc fragment, slowing clearance to ~5 days for weekly dosing.
Boxed warning for thyroid C-cell tumors.
References
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