GLP-1

Dulaglutide

Also known as Trulicity

Dulaglutide (Trulicity) is a once-weekly diabetes injection in the GLP-1 family that lowers blood sugar and reduces appetite.

One-dose burn-down
Half-life
4.7 days
Tmax
36 h
Bioavailability
65%
Steady state
~14d
Typical dose
0.75 mg

Once-weekly GLP-1 receptor agonist for type 2 diabetes.

Mechanism of action

GLP-1 analog fused to an IgG4 Fc fragment, slowing clearance to ~5 days for weekly dosing.

Boxed warning for thyroid C-cell tumors.

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FDA Prescribing Information (DailyMed)

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