Semaglutide
Also known as Ozempic, Wegovy, Rybelsus
Semaglutide is the weekly GLP-1 injection behind Ozempic and Wegovy. It curbs appetite and slows stomach emptying so you feel full on less food — used for type 2 diabetes and weight loss.
Long-acting GLP-1 receptor agonist for type 2 diabetes (Ozempic/Rybelsus) and chronic weight management (Wegovy). Dosed once weekly subcutaneously.
Mechanism of action
Albumin-bound GLP-1 analog resistant to DPP-4 degradation. Enhances glucose-dependent insulin secretion, suppresses glucagon, slows gastric emptying, and reduces appetite via central GLP-1 receptors.
Boxed warning for thyroid C-cell tumors (rodent data). Titrate slowly to limit GI effects. Half-life ~1 week means ~5 weeks to reach steady state and ~5 weeks to wash out.
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