Bivalirudin
Also known as Angiomax, Hirulog
One-dose burn-down
Half-life
25 min
Tmax
6 min
Bioavailability
100%
Typical dose
0.75 mg
Direct thrombin inhibitor used as a procedural anticoagulant during PCI/angioplasty. Given intravenously by weight.
Mechanism of action
Reversibly binds thrombin's catalytic site and substrate groove, directly inhibiting clot formation.
Approved drug — IV, procedural use only under clinical supervision. Very short half-life (~25 min); cleared faster with normal renal function.
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