Bivalirudin
Also known as Angiomax, Hirulog
Bivalirudin is an approved fast-acting blood thinner given in hospitals during procedures like angioplasty to stop dangerous clots from forming.
How one dose clears
modeled over ~6 half-lives- Half-life
- 25 min
- Time to peak (Tmax)
- 6 min
- Bioavailability
- 100%
- Typical dose
- 0.75 mg
Direct thrombin inhibitor used as a procedural anticoagulant during PCI/angioplasty. Given intravenously by weight.
Mechanism of action
Reversibly binds thrombin's catalytic site and substrate groove, directly inhibiting clot formation.
Approved drug — IV, procedural use only under clinical supervision. Very short half-life (~25 min); cleared faster with normal renal function.
References
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